کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5156686 | 1500586 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular weight and helix conformation determine intestinal anti-inflammatory effects of exopolysaccharide from Schizophyllum commune
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کلمات کلیدی
Sulfasalazine (PubChem CID: 5359476)Hematoxylin (PubChem CID: 442514)Exopolysaccharide - اگزو پلی ساکاریدConformation - سازگاریAnti-inflammatory activity - فعالیت ضد التهابیMolecular weight - وزن مولکولیHydrogen Peroxide (PubChem CID: 784) - پراکسید هیدروژن (PubChem CID: 784)Schizophyllum commune - کمون Schizophyllum
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Intestinal anti-inflammatory activities of exopolysaccharide from S. commune were assessed using dextran sulfate sodium (DSS)-induced colitis in mice model. The changes of molecular weight (MW), atomic force microscope morphology, X-ray diffraction, particle size distribution, and viscosity were recorded after sonication treatment. The results indicated that the triple helical structure of exopolysaccharide was dissociated into single helical structure and random coiled structure by ultrasonication via breaking of inter- and intramolecular hydrogen bonds. The medium (936Â kDa) and high MW (1437Â kDa) exopolysaccharide had the mixture of triple helix and single helix conformation, while the low MW (197Â kDa) exopolysaccharide exhibit random coiled conformation. The intestinal anti-inflammatory activity study showed that oral administration of medium and high MW (1437Â kDa) exopolysaccharide significantly recovered DSS-induced colitis in inflamed tissues and reduced inflammation induced infiltration of macrophages. These results showed that medium (936Â kDa) and high MW (1437Â kDa) exopolysaccharide had intestinal anti-inflammatory activity. The intestinal anti-inflammatory activity of exopolysaccharide was related to helical structure and molecular weight.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 172, 15 September 2017, Pages 68-77
Journal: Carbohydrate Polymers - Volume 172, 15 September 2017, Pages 68-77
نویسندگان
Bin Du, Yuedong Yang, Zhaoxiang Bian, Baojun Xu,