Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam

► Pitipeptolides C-F are identified from a marine cyanobacterium from Guam. ► Pitipeptolides possess weak cytotoxic activity against cancer cell lines. ► Pitipeptolides possess moderate antimycobacterial activity. ► Structural requirements for anticancer and antibacterial activities are different.