Naphthoquinone spiroketal with allelochemical activity from the newly discovered endophytic fungus Edenia gomezpompae

Bioactivity-directed fractionation of the culture of the Ascomycota fungus Edenia gomezpompae, led to the characterization of three new bioactive naphthoquinone spiroketals: preussomerin EG1 (1), preussomerin EG2 (2) and preussomerin EG3 (3). All compounds caused significant inhibition of the diametar growth of four phytopathogenic microorganisms. Compound 1 and acetylated derivatives also significantly inhibited the diametar growth of other endophytic fungi.