کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5177134 | 1380850 | 2012 | 5 صفحه PDF | دانلود رایگان |
Purification of n-BuOH fraction from 80% ethanol extract of Hypericum thasium Griseb. resulted in the isolation of three new compounds 3â²,4,5â²-trihydroxy-6-methoxy-2-O-α-l-arabinosylbenzophenone (1), 3â²,4,5â²,6-tetrahydroxy-2-O-α-l-arabinosylbenzophenone (2), and 3â²,4-dihydroxy-5â²-methoxy-2-O-α-l-arabinosyl-6-O-β-d-xylosylbenzophenone (3) along with a known flavonoid glycoside quercetin-3-O-α-l-arabinofuranoside (4). The structures of the new compounds were elucidated by 1D and 2D NMR analysis as well as HRESIMS. The isolated compounds (1-4), as well as quercetin, and kaempferol previously isolated from EtOAc fraction were screened against MAO-A inhibitory activity. When tested against the MAO-A quercetin and kaempferol displayed IC50 values of 19.6, and 17.5 μM, respectively. The IC50 values for MAO-A inhibition by compounds (1-4) were 310.3, 111.2, 726.0, and 534.1 μM, respectively. Standard inhibitor (clorgyline) exhibited MAO-A inhibition with an IC50 value of 0.5 μM.
Highlights⺠Three new compounds were isolated from Hypericum thasium Griseb. ⺠The new compounds were identified as benzophenone glycosides. ⺠The isolated compounds were screened against MAO-A inhibitory activity. ⺠This work is the first report about benzophenones as MAO-A inhibitors.
Journal: Phytochemistry Letters - Volume 5, Issue 4, December 2012, Pages 700-704