Anthraquinone glycosides from marine Streptomyces sp. strain

Two new anthraquinone glycosides Strepnoneside A (1) and Strepnoneside B (2), together with Chromomycin A3 (3), were isolated from cultures of the marine Streptomyces sp. strain. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Compound 3 exhibited cytotoxic activities against HCT 116 cell lines (IC50 = 300 ± 11 pM).

Two new anthraquinone glycosides, together with Chromomycin A3, were isolated from cultures of the marine Streptomyces sp. strain. Their structures were determined by spectroscopic methods.Highlights► Two anthraquinone glycosides and Chromomycin A3 were isolated from marine Streptomyces sp. strain. ► The structures of the new compounds were determined by detailed analysis of spectral data. ► Compound 3 exhibited cytotoxic activities against HCT 116 cell lines.