کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5202576 | 1381904 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glutathione-responsive biodegradable polyurethanes based on dithiodiundecanol
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Biodegradable polyurethanes were prepared from 11,11â²-dithiodiundecanol employed as soft segment incorporating hexamethylene diisocyanate (HDI) and 1,4-butanediol (BDO) serving as hard segment. The disulfide bonds in dithiodiundecanol could be cleaved into thiols in the presence of glutathione (GSH) through disulfide-thiol exchange reaction, which fulfilled the polyurethanes with responsive biodegradability. In vitro degradation test in PBS buffer at 37 °C, the molecular weight of polyurethanes substantially decreased and the surface morphology was significantly eroded after 8 days. The degradation reaction constants were calculated and kinetic equations were established.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 97, Issue 11, November 2012, Pages 2294-2300
Journal: Polymer Degradation and Stability - Volume 97, Issue 11, November 2012, Pages 2294-2300
نویسندگان
Jing Wang, Peiyu Sun, Zhen Zheng, Fangjie Wang, Xinling Wang,