کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5204681 | 1381968 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Self-accelerated biodegradation of electrospun poly(ethylene glycol)-poly(l-lactide) membranes by loading proteinase K
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Proteinase K was successfully loaded inside ultrafine fibers of poly(ethylene glycol)-poly(l-lactide) (PELA) by emulsion electrospinning. A core/shell fiber structure was formed and verified by a transmission electron microscope. In vitro biodegradation of electrospun PELA membranes containing proteinase K (PELA-P) was examined in Tris-HCl buffer solution at pH 8.6 and 37 °C in comparison with electrospun PELA membranes without proteinase K. During biodegradation, mass loss, water absorption, pH value of the incubated buffer, fibrous morphology and thermal properties were monitored. Results suggested that PELA-P membranes degraded significantly faster than PELA membranes. A significant drop in pH value of the buffer after incubation of PELA-P membranes for 1 d was observed, and after 7 d, PELA-P membranes lost their fibrous appearance and masses almost completely. In contrast, electrospun PELA membranes did not show any obvious changes. The obtained electrospun PELA-P membranes exhibited self-accelerated biodegradability and could benefit drug controlled release and tissue regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 93, Issue 3, March 2008, Pages 618-626
Journal: Polymer Degradation and Stability - Volume 93, Issue 3, March 2008, Pages 618-626
نویسندگان
Xiaoran Li, Hong Zhang, Hua Li, Gongwen Tang, Yunhui Zhao, Xiaoyan Yuan,