کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5209271 1503050 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glycyrrhetinic acid-modified PEG-PCL copolymeric micelles for the delivery of curcumin
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Glycyrrhetinic acid-modified PEG-PCL copolymeric micelles for the delivery of curcumin
چکیده انگلیسی

In this study, glycyrrhetinic acid (GA) was conjugated with mono amino poly (ethylene glycol)-b-poly (ε-caprolactone) (H2N-PEG-PCL) with succinate linker to obtain the GA-modified PEG-PCL (GA-PEG-PCL). By way of thin film hydration method, curcumin was encapsulated into GA-PEG-PCL copolymer to form stable micelles with 93.76% of encapsulation efficiency and 11.93% of drug loading capacity. The micelles enhanced curcumin's water-solubility to 1.87 mg/ml, being 1.70 × 105 times higher than free curcumin. X-ray diffraction and FT-IR analysis confirmed the encapsulation of CUR into copolymeic micelles with an amorphous state. Hemolysis datum of blank micelles showed its biocompatibility. Compared with GA-unconjugated micelles, curcumin-loaded GA-PEG-PCL micelles showed slower in vitro release of drug, but they displayed better in vitro cytotoxicity against HepG2 at about 40 μM because of its selective accumulation in HepG2 cells induced by GA.The results showed that GA-PEG-PCL copolymer could be a promising drug carrier for liver targeted drug delivery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 111, February 2017, Pages 30-37
نویسندگان
, , , , , , ,