کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5209421 1503058 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Facile synthesis of amphiphilic poly(ethylene glycol) conjugate and its micellization as injectable targeted vehicle for DOX
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Facile synthesis of amphiphilic poly(ethylene glycol) conjugate and its micellization as injectable targeted vehicle for DOX
چکیده انگلیسی
Amphiphilic FA-PEG2000-OA conjugate was designed, comprising hydrophilic poly(ethylene glycol) (PEG), with a folate targeting moiety and a biodegradable hydrophobic oleic acid (OA) segment at each chain ends. The near-monodisperse flower-shaped folate-functionalized micelles were self-assembled in aqueous solution for the folate receptor (FR)-mediated targeted delivery of the anticancer drug (doxorubicin (DOX)) to cancer cells. The drug loading and in vitro pH responsive controlled release performance revealed that the FA-PEG2000-OA micelles had potential application as drug delivery systems (DDS) for hydrophobic anthracycline anti-cancer drugs such as DOX. With the aid of FA-PEG2000-OA micelles as DDS, which was non-cytotoxic in low concentrations, the cancer cell-killing ability of DOX has been obviously enhanced, demonstrating their promising applications to overcome multi-drug resistance (MDR) in tumor treatments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 103, June 2016, Pages 54-62
نویسندگان
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