کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5215111 | 1383217 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemoenzymatic approach to optically active 1,4-dihydropyridine derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of racemic (2-methyl)propanoyloxymethyl 4-aryl-6-chloro-5-methanoyl-2-methyl-1,4-dihydropyridine-3-carboxylates [(±)-5a-h] have been prepared by a four step sequence including a multicomponent Hantzsch process and a Vilsmeier-Haack reaction. The subsequent resolution of (±)-5a-h was carried out by means of lipase-catalyzed hydrolysis, the most adequate enzymes being lipases from Candida rugosa (CRL) and Candida antarctica (CAL-B). The moderate to high enantioselectivities values (E up to >200) obtained in most cases allowed us to obtain the corresponding optically active 1,4-dihydropyridine derivatives with high enantiomeric excesses (eeâ¥94%) and yields.
88
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 71, Issue 23, 10 June 2015, Pages 3976-3984
Journal: Tetrahedron - Volume 71, Issue 23, 10 June 2015, Pages 3976-3984
نویسندگان
Susana Y. Torres, Yamila Verdecia, Francisca Rebolledo,