کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5215420 | 1383229 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Methylhydrazine-induced enantioselective α-hydroxylation of β-keto esters with molecular oxygen catalyzed by hydroquinine
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Methylhydrazine-induced α-hydroxylation of β-dicarbonyl compounds was achieved using O2 as the oxygen source. This reaction provides an efficient approach to enantioenriched ɑ-hydroxy β-dicarbonyl compounds, which are valuable substances and widely used in the chemical and pharmaceutical industry. A wide variety of β-keto esters could undergo this oxidation to give the corresponding products in excellent yields (up to 95%) and with good enantioselectivities (up to 85% ee). The mild reaction conditions and the use of molecular oxygen as oxidant make this protocol very environmentally friendly and practical.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 71, Issue 1, 7 January 2015, Pages 85–90
Journal: Tetrahedron - Volume 71, Issue 1, 7 January 2015, Pages 85–90