کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5220356 | 1383385 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytotoxic cycloartane triterpenes from the roots of Cimicifuga heracleifolia
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Phytochemical investigation on the roots of Cimicifuga heracleifolia afforded nine new 9,19-cycloartane triterpenes (1–9), along with seven known constituents (10–16). The new structures were elucidated by spectroscopic and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines indicated that eight cimigenol-type compounds (1–3, 5, 10–12, 14) showed different levels of cytotoxic activities, with IC50 values ranging from 0.83 to 23.94 μM. In addition, their structural and bioactive features enriched the structure–activity relationships we proposed before.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 68, Issue 32, 12 August 2012, Pages 6521–6527
Journal: Tetrahedron - Volume 68, Issue 32, 12 August 2012, Pages 6521–6527