Direct ortho-arylation of 2-arylbenzoxazoles via C–H activation

A new and highly regioselective arylation of 2-arylbenzoxazoles based on C–H activation has been developed. The results represent the first examples of palladium-catalyzed direct ortho-arylation of 2-arylbenzoxazoles and also provide a facile route for the synthesis of complicated structures containing arylated benzoxazoles moieties.

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