Synthesis of biantennary LacNAc-linked O-glycan (core 4) and glycopeptide thioester by benzyl protection strategy: rapid zinc reduction of GlcNTCA to GlcNAc by microwave irradiation

Synthesis of core 4 O-glycan and solid-phase synthesis of an O-glycan analog of the emmprin (Gly34-Gly58) segment are described. Microwave accelerated Zn/AcOH reduction of trichloroacetamides to acetamides.