کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5263419 1385214 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and tautomerism of spiro-pyrazolines
ترجمه فارسی عنوان
سنتز و تاتومریسی اسپیرو پریآزولین
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
An experimental study on the synthesis, tautomerism, and acid promoted structural changes of spiro-pyrazolines is described. The target was achieved through a [3+2]-dipolar cycloaddition of an alkene with nitrile imines generated in situ and was isolated in high yield. The synthesized cycloadduct displayed a tendency to exhibit an imine-enamine type of tautomerism as evidenced by X-ray crystal and NMR studies. Furthermore, addition of an acid resulted in the transformation of an imine tautomer to an enamine. The current report constitutes a first formal observation of this kind of tautomerism observed in spiro-indoline pyrazolines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 14, 2 April 2014, Pages 2208-2211
نویسندگان
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