Ligand free open air copper(II) mediated aryl formamidation and amination of aryl halides

- Direct foramidation procedure of electron rich aromatic halides was developed.
- Aryl amination was performed on open air without copper ligand.
- Economical approach to aryl C-N bond formation.
- Copper(II) sulfate mediated reactions.

A simple synthetic procedure for direct formamidation and amination of aryl halides mediated by copper(II) salts was developed in open air, without an external ligand in formamide with potassium carbonate as a base. This approach is particularly efficient when electron active aryl halides are used as substrates. In these cases almost quantitative formamidation was observed.