A novel approach for the synthesis of Crizotinib through the key chiral alcohol intermediate by asymmetric hydrogenation using highly active Ir-Spiro-PAP catalyst

A novel approach for the synthesis of Crizotinib through the key chiral alcohol intermediate by asymmetric hydrogenation using highly active Ir-Spiro-PAP catalyst

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 9, 26 February 2014, Pages 1528-1531

Jian-Qiang Qian, Pu-Cha Yan, Da-Qing Che, Qi-Lin Zhou, Yuan-Qiang Li,