کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5284027 | 1385729 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solvent effects on the diastereoselection in LiAlH4 reduction of α-substituted ketones
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Based on high-level DFT calculations including solvent molecules, it was found that steric effects of solvent may be responsible for the diastereoselection in LiAlH4 reduction of acyclic ketones substituted by an oxygen-containing functional group at the α-position to the carbonyl. It was concluded that the conventional chelated transition state models lead to the predominance of the Râ,Sâ-diastereoisomers against experimental observation.
It was found that steric effects of solvent may be responsible for the diastereoselection in LiAlH4 reduction of acyclic ketones.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 27, 30 June 2008, Pages 4223-4226
Journal: Tetrahedron Letters - Volume 49, Issue 27, 30 June 2008, Pages 4223-4226
نویسندگان
Yasumitsu Suzuki, Daisuke Kaneno, Masaya Miura, Shuji Tomoda,