کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5370739 | 1503905 | 2016 | 14 صفحه PDF | دانلود رایگان |
- A mutation of hemoglobin inducing Sickle cell anemia is the first molecular disease.
- The atomic structure of proteins opened new perspectives in molecular medicine.
- Protein misfolding is a critical event triggering neurodegenerative diseases.
- The Retromer is involved in the molecular mechanism of several neurological disorders.
Molecular medicine is founded on the synergy between Chemistry, Physics, Biology and Medicine, with the ambitious goal of tackling diseases from a molecular perspective. This Review aims at retracing a personal outlook of the birth and development of molecular medicine, as well as at highlighting some of the most urgent challenges linked to aging and represented by incurable neurodegenerative diseases caused by protein misfolding. Furthermore, we emphasize the emerging role of the retromer dysfunctions and improper protein sorting in Alzheimer's disease and other important neurological disordered.
Journal: Biophysical Chemistry - Volumes 214â215, JulyâAugust 2016, Pages 33-46