کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5372486 | 1388884 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bead-like passage of chloride ions through ClC chloride channels
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The ClC chloride channels control the ionic composition of the cytoplasm and the volume of cells, and regulate electrical excitability. Recently, it has been proposed that prokaryotic ClC channels are H+-Clâ exchange transporter. Although X-ray and molecular dynamics (MD) studies of bacterial ClC channels have investigated the filter open-close and ion permeation mechanism of channels, details have remained unclear. We performed MD simulations of ClC channels involving H+, Na+, K+, or H3O+ in the intracellular region to elucidate the open-close mechanism, and to clarify the role of H+ ion an H+-Clâ exchange transporter. Our simulations revealed that H+ and Na+ caused channel opening and the passage of Clâ ions. Na+ induced a bead-like string of Clâ-Na+-Clâ-Na+-Clâ ions to form and permeate through ClC channels to the intracellular side with the widening of the channel pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biophysical Chemistry - Volume 120, Issue 1, 1 March 2006, Pages 36-43
Journal: Biophysical Chemistry - Volume 120, Issue 1, 1 March 2006, Pages 36-43
نویسندگان
Atsushi Suenaga, Jay Z. Yeh, Makoto Taiji, Akira Toyama, Hideo Takeuchi, Mingyu Son, Kazuyoshi Takayama, Masatoshi Iwamoto, Ikuro Sato, Toshio Narahashi, Akihiko Konagaya, Kunihiko Goto,