کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5433354 | 1508986 | 2017 | 10 صفحه PDF | دانلود رایگان |
Artificial cationic helical peptides possess an enhanced cell-penetrating property. However, their cell-penetrability is not converted by cellular environmental changes resulting in nonspecific uptake. In this study, pH-sensitive anion-donating groups were added to a helical polypeptide to simultaneously achieve tumor targeting and pro-apoptotic activity. The mitochondria-destabilizing helical polypeptide undergoing pH-dependent conformational transitions selectively targeted cancer cells consequently disrupting mitochondrial membranes and subsequently inducing apoptosis. This work presents a promising peptide therapeutic system for cancer therapy.
Mitochondria-destabilizing helical polypeptide undergoing a pH-activated conformational transition selectively perturbed the mitochondrial outer membranes thereby inducing pro-apoptosis.74
Journal: Journal of Controlled Release - Volume 264, 28 October 2017, Pages 24-33