کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5433925 1509002 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
First in vivo MRI study on theranostic dendrimersomes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
First in vivo MRI study on theranostic dendrimersomes
چکیده انگلیسی

Amphiphilic Janus-dendrimers are able to self-assemble into nanosized vesicles named dendrimersomes. We recently synthesized the 3,5-C12-EG-(OH)4 dendrimer that generates dendrimersomes with very promising safety and stability profiles, that can be loaded with different contrast agents for in vivo imaging. In this contribution, nanovesicles were loaded with both the Magnetic Resonance Imaging (MRI) reporter GdDOTAGA(C18)2 and the glucocorticoid drug Prednisolone Phosphate (PLP), in order to test their effective potential as theranostic nanocarriers on murine melanoma tumour models. The incorporation of GdDOTAGA(C18)2 into the membrane resulted in dendrimersomes with a high longitudinal relaxivity (r1 = 39.1 mM− 1 s− 1, at 310 K and 40 MHz) so that, after intravenous administration, T1-weighted MRI showed a consistent contrast enhancement in the tumour area. Furthermore, the nanovesicles encapsulated PLP with good efficiency and displayed anti-tumour activity both in vitro and in vivo, thus enabling their practical use for biomedical theranostic applications.

Dendrimersomes loaded with both the MRI reporter GdDOTAGA(C18)2 and the glucocorticoid drug Prednisolone Phosphate (PLP) displayed in vitro and in vivo efficacy in the treatment of murine melanoma.143

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 248, 28 February 2017, Pages 45-52
نویسندگان
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