کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5434209 | 1509140 | 2017 | 7 صفحه PDF | دانلود رایگان |
- A novel gas-liquid microfluidic approach is used to build LbL-assembled capsules.
- This approach can build the multilayer capsule with favorable cavities in each layer.
- Various components can be separately encapsulated in different layer cavities.
- Τhis LbL-assembled capsule is an attractive candidate for biomedical applications.
In this work, a layer-by-layer (LbL) assembled biopolymer microcapsule with separate layer cavities is generated by a novel and convenient gas-liquid microfluidic approach. This approach exhibits combined advantages of microfluidic approach and LbL assembly method, and it can straightforwardly build LbL-assembled capsules in mild aqueous environments at room temperature. In particular, using this approach we can build the polyelectrolyte multilayer capsule with favorable cavities in each layer, and without the need for organic solvent, emulsifying agent, or sacrificial template. Various components (e.g., drugs, proteins, fluorescent dyes, and nanoparticles) can be respectively encapsulated in the separate layer cavities of the LbL-assembled capsules. Moreover, the encapsulated capsules present the ability as colorimetric sensors, and they also exhibit the interesting release behavior. Therefore, the LbL-assembled biopolymer capsule is a promising candidate for biomedical applications in targeted delivery, controlled release, and bio-detection.
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Journal: Materials Science and Engineering: C - Volume 81, 1 December 2017, Pages 13-19