Near infrared radiated stimulus-responsive liposomes based on photothermal conversion as drug carriers for co-delivery of CJM126 and cisplatin

- CJM126 coupled with cholesterol derivative and lecithin blend to produce liposomes were sustainable and biodegradable.
- The prepared liposomes co-deliver two drugs of CJM126 and cisplatin for the purpose of synergistic therapy.
- The Indocyanine green (ICG) possess the capability to convert near infrared into heat to control the release of drug molecules from nanocarriers.
- A glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein, folate was used as the ligand to conjugate on the liposomes to target folate receptors (FR) which overexpressed on the surface of a variety of human tumor cells.

Synergistic therapy has caused increasing interest in recent treatment of cancer owing to its preferable therapeutic efficiency to most single antineoplastic protocol. Herein, we design a co-delivery two drugs nanosystem based on biodegradable liposomes, loading cisplatin, Indocyanine green (ICG), and CJM126 coupled with cholesterol derivative (CJM-Chol) for the purpose of synergistic therapy. The obtained nanoparticles showed a uniform diameter of 103.8 nm and a favorable morphology. The investigation on near infrared radiated (NIR) responsive release showed that NIR mediated photothermal conversion induced a controllable drug release from liposomes. Furthermore, the designed liposomes (only 50 μg/mL) displayed an inspiring photothermal conversion efficiency and received a high temperature (65.6 °C, Tm = 42 °C) when exposed to an 808 nm near infrared laser (1.54 W, 5 min). Besides, it turned out that the delivery system could be efficiently endocytosed by tumor cells, which attributed to its admirable biocompatibility and the targeting role of folate. The prepared nanoparticles showed significantly excellent inhibitory effect (3.05% cell viability in 24 h) on MDA-MB-231 cells when added irradiation as compared with free cisplatin (28.41%) or treatment without NIR (11.24%) in our study. Our research highlights the present nanoparticles provide a promising strategy for targeted delivery and photothermal treatment.