کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5434389 1509143 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of solvents and hydrophilic additive on stable coating and controllable sirolimus release system for drug-eluting stent
ترجمه فارسی عنوان
تأثیر حلالها و افزودنی هیدروفیلی روی پوشش پایدار و سیستم آزمایشی قابل کنترل سیرولوزیس برای استنت
کلمات کلیدی
استنت ساییدگی مواد مخدر، پلیمر زیست تخریب پذیر، سیرولیموس، پوشش التراسونیک، انتشار مواد مخدر،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


- The morphology of sirolimus coating layer was stable without irregularity or roughness under optimal coating conditions.
- Sirolimus was sustained release from PDLLA coating layer coated on the stent.
- A controllable drug release system was designed using different types of solvents and F127 additive.
- The molecular size of sirolimus in THF was larger than that in chloroform.
- Provide helpful information for understanding the sirolimus behavior in polymer solution based on organic solvents.

Various drug-eluting stents (DESs) have been developed to prevent restenosis after stent implantation. However, DES still needs to improve the drug-in-polymer coating stability and control of drug release for effective clinical treatment. In this study, the cobalt-chromium (CoCr) alloy surface was coated with biodegradable poly(D,L-lactide) (PDLLA) and sirolimus (SRL) mixed with hydrophilic Pluronic F127 additive by using ultrasonic spray coating system in order to achieve a stable coating surface and control SRL release. The degradation of PDLLA/SRL coating was studied under physiological solution. It was found that adding F127 reduced the degradation of PDLLA and improved the coating stability during 60 days. The effects of organic solvent such as chloroform and tetrahydrofuran (THF) on the coating uniformity were also examined. It was revealed that THF produced a very smooth and uniform coating compared to chloroform. The patterns of in vitro drug release according to the type of organic solvent and hydrophilic additive proposed the possibility of controllable drug release design in DES. It was found that using F127 the drug release was sustained regardless of the organic solvent used. In addition, THF was able to get faster and controlled release profile when compared to chloroform. The structure of SRL molecules in different organic solvents was investigated using ultra-small angle neutron scattering. Furthermore, the structure of SRL is concentration-dependent in chloroform with tight nature under high concentration, but concentration-independent in THF. These results strongly demonstrated that coating stability and drug release patterns can be changed by physicochemical properties of various parameters such as organic solvents, additive, and coating strategy.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 78, 1 September 2017, Pages 39-46
نویسندگان
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