کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5434960 | 1509148 | 2017 | 8 صفحه PDF | دانلود رایگان |
- Carboxylmethyl chitosan (CMCS) was grafted onto magnetic nanoparticles (MNPs) as a retrievable antimicrobial agent.
- Silver nanoparticles was in situ formed on grafted CMCS matrix.
- Dual action of CMCS and AgNPs significantly enhanced the antimicrobial activity against planktonic cells as well as biofilm.
- Antimicrobial activity of MNPs@CMCS-Ag is retrievable and deliverable via an applied magnetic field.
Carboxymethyl chitosan (CMCS) was known to have a much better antimicrobial activity than chitosan due to the increased cationic -NH3+ groups resulted from the intra- and intermolecular interactions between the carboxyl and amino groups. CMCS was grafted onto the surface of silica coated magnetic nanoparticles (MNPs) to obtain magnetically retrievable and deliverable antimicrobial nanoparticles (MNPs@CMCS). The presence of carboxylate groups in CMCS not only enhanced antimicrobial activity but also enabled Ag ions chelating ability to induce the in situ formation of Ag nanoparticles (AgNPs). The deposition of AgNPs on the surface of MNPs@CMCS could significantly increase its antimicrobial activity against planktonic cells due to the dual action of CMCS and AgNPs. Due to its high magnetism, the as-prepared MNPs@CMCS-Ag could be efficiently delivered into an existing biofilm under the guidance of an applied magnetic field. Without direct contact, the Ag ions and/or radical oxygen species (ROS) released from the deposited Ag nanoparticles could effectively kill the bacteria embedded in the extracellular polymeric substances (EPS) matrix of biofilm.
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Journal: Materials Science and Engineering: C - Volume 73, 1 April 2017, Pages 544-551