The electro-synthesized imprinted PEDOT film as a simple voltammetric sensor for highly sensitive and selective detection of vitamin K3 in poultry drug samples

- A novel and facile molecular imprinted polymer were successfully fabricated to detect vitamin K3 in poultry drug.
- The PEDOT-MIP sensor revealed good selectivity, wide linear range and low detection lmit toward vitamin K3.
- Excellent reproducibility and stability of the PEDOT-MIP sensor.

Poly(3,4-ethylenedioxythiophene) (PEDOT) as a potential molecularly imprinted polymer (MIP) for the promising application in different fields is being closely concerned, but the denseness and smoothness in the morphology and structure of PEDOT hinder the application of the imprinted PEDOT film. In this paper, a simple voltammetric sensor with high sensitivity and selectivity based on the imprinted PEDOT film with imprinted sites as a recognition element for the trace analysis of vitamin K3 (VK3) in poultry drug samples was developed by the one-step electro-polymerization of commercially-available monomer 3,4-ethylenedioxythiophene in the presence of the template molecule VK3. The imprinted PEDOT/GCE could efficiently discriminate VK3 from its structural analogs, and the imprinted PEDOT sensor displayed good linearity with VK3 concentrations in the wide range of 0.009 to 35 μM with a low limit of detection 0.00031 μM under the optimal conditions. The proposed method was successfully applied for the selective determination of VK3 in poultry drug samples. All results indicated that the proposed imprinted electrode will provide a promising mimetic sensing platform for the determination of VK3 in animal feedstuffs, livestock products and veterinary drugs.

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