کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5464022 | 1517195 | 2017 | 4 صفحه PDF | دانلود رایگان |
- Making VEGF-containing PLGA scaffolds via negative-voltage emulsion electrospinning.
- Encapsulating VEGF in the core of core-shell structured biodegradable nanofibers.
- Realizing steady and sustained release of VEGF from nanofibrous scaffolds.
- Enhancing endothelial cell functions using VEGF-containing scaffolds.
Electrospun nanofibrous scaffolds providing local delivery of vascular endothelial growth factor (VEGF) have distinctive advantages for vascular tissue engineering. However, more than 90% of VEGF were normally released from scaffolds formed by conventional positive-voltage emulsion electrospinning (PVEES) within the initial 3Â days. VEGF molecules bear positive charge. In this investigation, emulsion electrospinning using power supplies of different polarities was studied for producing scaffolds bearing specific electric charge. VEGF-containing poly(lactic-co-glycolic acid) scaffolds with initial potential of â87 and â202Â V were formed by negative-voltage emulsion electrospinning (NVEES) at â10 and â20Â kV, respectively, which enabled steady and sustained release up to 18Â days, exhibiting effective modulation for VEGF release. Compared to VEGF-containing scaffolds formed by PVEES, NVEES-formed scaffolds showed superior performance in promoting endothelial cell functions.
Journal: Materials Letters - Volume 193, 15 April 2017, Pages 1-4