کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5491366 | 1524998 | 2018 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural impacts on the timing and amplitude of the negative BOLD response
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک ماده چگال
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چکیده انگلیسی
The positive (PBR) and negative BOLD responses (NBR) arising in task-fMRI display varying magnitudes and dynamics across voxels. While the effects of structure, particularly of veins, on the PBR have been studied, little is known of NBR-structure relationships. Like the PBR, the NBR is often used as a surrogate marker of neuronal activation in both basic and clinical research and assessing its relationship with cortical structure may help interpret group differences. We therefore investigated how local structure affects BOLD amplitude and timing in PBR and NBR areas using multi-band fMRI during visual stimulation to obtain high temporal resolution (TRÂ =Â 0.45Â s) data combined with T1 imaging and susceptibility-weighted imaging (SWI) to quantify the local densities of gray/white matter and veins, respectively. In both PBRs and NBRs, larger venous density was consistently associated with larger BOLD amplitude and delay, up to 1-2Â s larger relative to areas devoid of large veins. Both binary and sinusoidal visual stimulus modulation yielded similar activation maps and results, suggesting that underlying vasculature affects PBR and NBR temporal dynamics in the same manner. Accounting for structural impacts on PBR and NBR magnitude and timing could help enhance activation map accuracy, better assess functional connectivity, and better characterize neurovascular coupling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Magnetic Resonance Imaging - Volume 45, January 2018, Pages 34-42
Journal: Magnetic Resonance Imaging - Volume 45, January 2018, Pages 34-42
نویسندگان
David Provencher, Alexandre Bizeau, Guillaume Gilbert, Yves Bérubé-Lauzière, Kevin Whittingstall,