کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5497734 | 1532070 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A systematic study on the utility of CHX-A''-DTPA-NCS and NOTA-NCS as bifunctional chelators for 177Lu radiopharmaceuticals
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This paper describes the evaluation of [(R)-2-Amino-3-(4-isothiocyanatophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-pentaacetic acid (CHX-A''-DTPA-NCS) and 2-S-(4-isothiocyanatobenzyl)â1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA-NCS) as bifunctional chelators for 177Lu. While 177Lu-CHX-A''-DTPA-NCS could be obtained in high yields at equimolar ratios of lutetium to CHX-A''-DTPA-NCS, >95% yield of 177Lu-NOTA-NCS could be achieved at 1:2Â M ratio of lutetium to NOTA-NCS. Trace metals reduced the yields of 177Lu-NOTA-NCS significantly as compared to 177Lu-CHX-A''-DTPA-NCS. In vitro stability of 177Lu-CHX-A''-DTPA-NCS was also superior to 177Lu-NOTA-NCS. It could be concluded from this study that among the two chelators evaluated, CHX-A''-DTPA-NCS is more appropriate for preparation of 177Lu radiopharmaceuticals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 127, September 2017, Pages 1-6
Journal: Applied Radiation and Isotopes - Volume 127, September 2017, Pages 1-6
نویسندگان
Usha Pandey, Naresh Gamre, Sharad Pandurang Lohar, Ashutosh Dash,