کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5516645 1542685 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of novel 4′-acylamino modified 21E-benzylidene steroidal derivatives and their cytotoxic activities
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Synthesis of novel 4′-acylamino modified 21E-benzylidene steroidal derivatives and their cytotoxic activities
چکیده انگلیسی


- A series of 4′-acylamino modified 21E-benzylidene derivatives 6a-v were synthesized.
- Their toxicity against brine shrimp and in vitro cytotoxic activities were evaluated.
- Compound 6f produced promising cytotoxic activity against HeLa and MCF-7 cells.

A series of 4′-acylamino modified Δ1,4-pregnadien-21E-benzylidene-3,20-dione derivatives (6a-v) was synthesized from the commercially available progesterone (1). These title compounds were evaluated for their toxicity against brine shrimp (Artemia salina) and cytotoxic activities against two human cancer cell lines (HeLa and MCF-7). The results revealed that compound 6f exhibited promising in vitro cytotoxic activity to the two cancer cell lines and the nature of acylamino functional group in the benzylidene moiety had a significant influence on cytotoxicity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 123, July 2017, Pages 20-26
نویسندگان
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