کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5517199 1400955 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bacterial Autophagy: Offense and Defense at the Host-Pathogen Interface
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Bacterial Autophagy: Offense and Defense at the Host-Pathogen Interface
چکیده انگلیسی

Autophagy is a fundamental cellular process used for the turnover and recycling of cytosolic components and damaged organelles. Originally characterized as a response to cellular stress, it now is well established that autophagy also is used as a defensive mechanism to combat the infection of host cells by intracellular pathogens. However, although this defensive strategy does limit the proliferation of most pathogens within their host cells, successful pathogens have evolved countermeasures that subvert or circumvent the autophagic response. In this review, we discuss the mechanisms used by a number of these pathogens to escape autophagy, with a particular focus on Salmonella enterica serovar Typhimurium, which has been the most extensively studied example. We also discuss the consequences of bacterial autophagy for the broader innate immune response.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular and Molecular Gastroenterology and Hepatology - Volume 4, Issue 2, September 2017, Pages 237-243
نویسندگان
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