کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5523997 1401403 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ghrelin and cancer progression
ترجمه فارسی عنوان
گرلین و پیشرفت سرطان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


- The molecular mechanism of ghrelin in cancer progression is illustrated.
- Ghrelin expression is clinically associated with cancer patient outcomes.
- Pan-cancer panel demonstrates ghrelin expressions in various types of cancer patients.

Ghrelin is a small peptide with 28 amino acids, and has been characterized as the ligand of the growth hormone secretagogue receptor (GHSR). In addition to its original function in stimulating pituitary growth hormone release, ghrelin is multifunctional and plays a role in the regulation of energy balance, gastric acid release, appetite, insulin secretion, gastric motility and the turnover of gastric and intestinal mucosa. The discovery of ghrelin and GHSR expression beyond normal tissues suggests its role other than physiological function. Emerging evidences have revealed ghrelin's function in regulating several processes related to cancer progression, especially in metastasis and proliferation. We further show the relative GHRL and GHSR expression in pan-cancers from The Cancer Genome Atlas (TCGA), suggesting the potential pathological role of the axis in cancers. This review focuses on ghrelin's biological function in cancer progression, and reveals its clinical significance especially the impact on cancer patient outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1868, Issue 1, August 2017, Pages 51-57
نویسندگان
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