کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5524671 1546493 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewAutophagy: A necessary event during erythropoiesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
ReviewAutophagy: A necessary event during erythropoiesis
چکیده انگلیسی

Autophagy is a well-known cellular process involved in many physiological and pathological processes. During erythropoiesis, autophagy plays an important role participating in the clearance of unnecessary organelles such as ribosomes and mitochondria (mitophagy) allowing the correct formation of mature red blood cells. The dysfunction of autophagy proteins hamper the correct erythroid maturation, leading to anemia, the release of immature cells from the bone marrow and other hematological abnormalities. Autophagy plays different roles depending on the type of pathology. In leukemia cells, it has been demonstrated that autophagy could be either detrimental, leading to an increase of the apoptosis rate, or protective, acting as a key process that augments proliferation and survival of cancer cells. Thus, understanding the relationship between autophagy and erythropoiesis opens new avenues for the discovery of biochemical and pharmacological targets and for the development of novel therapeutic approaches.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Reviews - Volume 31, Issue 5, September 2017, Pages 300-305
نویسندگان
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