Mini-reviewmiRNAs in B-cell lymphoma: Molecular mechanisms and biomarker potential

- MicroRNAs (miRNAs) are aberrantly expressed in all B-cell lymphomas.
- The same miRNAs control key functions in both B-cell development and lymphomagenesis.
- Aberrant miRNA expression is linked to aberrant gene expression in most B-cell lymphoma types.
- They have great potential as liquid biopsy biomarkers for diagnosis, prognosis and prediction.

MicroRNAs (miRNAs) are small non-coding RNAs that regulate many human genes including those involved in normal B-cell development. When these miRNAs are aberrantly expressed in B-cells they play key pathogenetic roles in the development and maintenance of B-cell lymphomas and by association may serve as useful biomarkers. In this review, we provide an overview of the importance of miRNAs to B-cell lymphomagenesis, as well as considering their use as biomarkers, and their potential usefulness for the clinic.