کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5526820 1547063 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review(Neo)adjuvant treatment in localised soft tissue sarcoma: The unsolved affair
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Review(Neo)adjuvant treatment in localised soft tissue sarcoma: The unsolved affair
چکیده انگلیسی


- The role of (neo)adjuvant chemotherapy (CT) in soft tissue sarcoma is still uncertain.
- A review of the main available evidences is provided, with a contemporary view.
- Is it possible to draw up the 'identikit' of the right candidate for adjuvant CT?
- What groundbreaking studies on (neo)adjuvant CT are currently ongoing?
- Future and collateral perspectives to the use of (neo)adjuvant CT are illustrated.

Soft tissue sarcomas (STS) are rare and heterogeneous tumours. A correct definition of STS is imperative from the very beginning of disease management, to guide the diagnostic and imaging work-up, and help to establish the prognosis on which the therapeutic strategy will be based. Over the last few years, many efforts have been made to identify characteristics that could predict disease behaviour and to enrich the therapeutic armamentarium against the advanced disease, that is still characterised by poor prognosis. Surgery remains the milestone of treatment for localised STS, whereas many uncertainties regarding the role of adjuvant and neoadjuvant treatment persist. Some controlled evidence is available, but often conflicting and insufficient to make chemotherapy (CT) a standard practice and, currently, a common and shared strategy does not exist. The biggest question concerns the prospective identification of the subgroup of patients who would benefit the most from (neo)adjuvant therapies. In light of the growing understanding of different biologies and sensitivities of the various sarcoma subtypes, the value of histology in the selection of peri-operative treatments is one of the most intriguing topics under discussion. In this perspective, a new generation of neoadjuvant trials have been planned and are currently ongoing.The aim of this review was to rekindle interest in the long-standing topic of (neo)adjuvant CT in localised STS, providing an update on its role in sarcomas' management and highlighting future directions and consequential factors needed to further improve outcomes in this disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 70, January 2017, Pages 1-11
نویسندگان
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