کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5527481 1547725 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic and epigenetic heterogeneity and the impact on cancer relapse
ترجمه فارسی عنوان
ناهمگنی ژنتیکی و اپیزیونیک و تاثیر آن بر سرطان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


- Genetic and epigenetic evolution can follow distinct and independent trajectories.
- New epigenetic technologies improve diagnostic accuracy and clinical application.
- Epigenetic CRISPR editing can reprogram the aberrant sites of DNA methylation.

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy with an exceedingly poor prognosis: a 5-year overall survival rate of 40%-45% in the young and a 5-year survival rate of less than 10% in the elderly (>60 years of age). Although a high percentage of patients enters complete remission after chemotherapeutic intervention, the majority of patients relapse within 3 years. Such stark prognostic outcomes highlight the need for additional clinical research, basic discovery, and molecular delineation of the etiologies and mechanisms behind responses to therapy that lead to relapse. Here, we summarize recent discoveries in tumor heterogeneity at the genetic and epigenetic levels and their independent molecular trajectories and dynamics in response to therapy. These new discoveries may have significant implications for understanding, monitoring, and treating leukemia and other cancers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Hematology - Volume 54, October 2017, Pages 26-30
نویسندگان
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