کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5527703 1547885 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperCost-effectiveness of methods in personalized medicine. Results of a decision-analytic model in patients with acute myeloid leukemia with normal karyotype
ترجمه فارسی عنوان
هزینه-اثربخشی روش ها در پزشکی شخصی. نتایج یک مدل تصمیم گیری تحلیلی در بیماران مبتلا به لوسمی میلوئیدی حاد با کارایوتیپ طبیعی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


- Molecular genetic data as prognostic/predictive factors in acute myeloid leukemia.
- Seven months longer life at US$ 32,000 more costs (molecular diagnostic strategy).
- Incremental cost-effectiveness ratio of about US$ 4928 per survived month.
- Costs of allogeneic transplantation are defined as cost driver.
- Method of personalized medicine can be interpreted as cost-effective (WHO approach).

BackgroundDuring the last years, molecular genetic data are increasingly used as prognostic and predictive factors in acute myeloid leukemia (AML). The molecular genetic profile permits a rapid risk categorization and beyond that a prediction of differential treatment efficacy of post-remission chemotherapy versus an allogeneic hematopoietic cell transplantation (HCT) in specific subgroups.MethodsThe aim of this study was to evaluate cost-effectiveness of two different strategies of risk categorization (conventional cytogenetic diagnostics (CCD) versus molecular genetic diagnostics (MGD)) in patients with AML, using a decision-analytic state-transition model. The model is run as (Monte Carlo) microsimulation in which individuals pass through in cycles with a cycle length of one month and a time horizon of ten years.FindingsResults show that on average, individuals within the MGD group generated about US$ 32,000 higher costs but survived about seven months longer than individuals within the CCD group. This leads to an Incremental Cost-Effectiveness Ratio (ICER) of about US$ 4928 per survived month.InterpretationWith a GDP (Gross Domestic Product) of US$ 26,467 (€ 33,630) per capita in Germany in 2012, the base-case ICER of US$ 4928 per survived month projected to US$ 59,136 per survived year is in between the simple GDP and the three times GDP per capita.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 62, November 2017, Pages 84-90
نویسندگان
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