کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529356 1401694 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleExpression of BMP-4 in papillary thyroid carcinoma and its correlation with tumor invasion and progression
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Original articleExpression of BMP-4 in papillary thyroid carcinoma and its correlation with tumor invasion and progression
چکیده انگلیسی

Bone morphogenetic protein 4 (BMP-4) is a member of the BMP protein family. BMP-4 was reported to induce epithelial-mesenchymal transition (EMT) and promote tumor cell immigration and invasion. This study aimed to investigate the expression of BMP-4 in papillary thyroid carcinoma (PTC) and its correlation with the patients' clinicophathological features and with tumor invasion and metastasis. Surgically resected PTC specimens from 82 patients admitted to the Department of Thyroid Surgery of Yantai Yuhuangding Hospital between Feb 1st and May 31st, 2016 were collected. The expression level of BMP-4 in PTC tissues was examined by immunohistochemical staining. The full clinical records of all patients were collected to analyze the relevance between BMP-4 expression and the clinical pathological features of PTC. Our result showed that BMP-4-positive cell rate and staining intensity were positively correlated with the patient's age (P = 0.031, 0.037), tumor size (P = 0.033, 0.019), capsular invasion (P = 0.001, 0.002) and TNM stage (P = 0.001, 0.004), while not correlated with gender, multicentricity of tumor or lymphatic metastasis. In conclusion, this study identified BMP-4 as a potential molecular marker for predicting the invasion and progression of PTC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 213, Issue 4, April 2017, Pages 359-363
نویسندگان
, , , , , , ,