کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5530752 1549388 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperComprehensive analysis of epigenetically regulated genes in anergic T cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Research paperComprehensive analysis of epigenetically regulated genes in anergic T cells
چکیده انگلیسی


- Comprehensive analysis of the gene expression of anergic T cells.
- Comprehensive analysis of the DNA methylation status of anergic T cells.
- Correlation of the gene expression and DNA methylation by using a GO analysis.

T cell anergy is one of the important mechanisms for immune tolerance. The results of many studies investigating the mechanism for T cell anergy induction have revealed that the expression of several genes was up-regulated in anergic T cells. It has also been demonstrated that the molecules encoded on those genes played a critical role in anergy induction. However, the mechanism for their up-regulation has not previously been clarified. We examined in this study the changes in gene expression and DNA methylation status caused by anergy induction. Our results demonstrate that the expression of many genes was changed by anergy induction, and that the DNA methylation status of some of these genes was also changed. We show here by a GO analysis that the extent of the change in methylation status caused by anergy induction was distinct between the groups of genes that were categorized.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 311, January 2017, Pages 71-79
نویسندگان
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