Mini reviewS100A7: A rAMPing up AMP molecule in psoriasis

- S100A7 (psoriasin) regulates many cell functions, including cell proliferation and differentiation.
- S100A7 production is dysregulated in many inflammatory contexts, such as in psoriasis.
- S100A7 is an emerging critical cytokine-like player in the psoriatic maintenance phase.
- Possible use of S100A7 as therapeutic target in psoriasis.

S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests that S100A7 plays critical roles in amplifying the inflammatory process in psoriatic skin, perpetuating the disease phenotype. This review will discuss the interactions between S100A7 and cytokines in psoriatic skin. Furthermore, we will focus our discussion on regulation and functions of S100A7 in psoriasis. Finally, we will discuss the possible use of S100A7 as therapeutic target in psoriasis.