کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5534928 1551359 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewMetabolic reprogramming of carcinoma-associated fibroblasts and its impact on metabolic heterogeneity of tumors
ترجمه فارسی عنوان
برنامه ریزی مجدد متابولیک فیبروبلاست های مرتبط با سرطان و تاثیر آن بر ناهمگنی متابولیکی تومورها
کلمات کلیدی
تومور، برنامه ریزی متابولیک، فیبروبلاست همراه با سرطان ناهمگونی متابولیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی

Tumor metabolism is characterized with up-regulated glucose uptake and glycolytic rate of tumor cells as the source of ATP and tumors growth, and regulated by a poorly defined combination of cell-intrinsic and extrinsic factors. Metabolic heterogeneity of human tumors is dependent upon the mutational status of specific oncogenes and influenced by tumor microenvironment. Carcinoma-associated fibroblasts (CAFs) adapt in a dynamic manner to the metabolic needs of cancer cells, associated with tumorigenesis and resistance to treatments. Importantly, CAFs could directly “feed” cancer cells essential nutrients and energy-rich metabolites, including lactate, ketone bodies, fatty acids, glutamine, and other amino acids through the induction of autophagy in a host-parasite pattern, to contribute to tumor growth and metastasis. To define the reciprocal metabolic interplay between CAFs and cancer cells will provide a better understanding of molecular mechanisms by which the treatment resistance occurs,and aid in the rational design of metabolism-based approaches to enhance the efficacy of immunotherapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 64, April 2017, Pages 125-131
نویسندگان
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