کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5549017 1556599 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells
چکیده انگلیسی


- Serotonin (5-HT) and noradrenaline (NA) elicit firing of cerebellar globular cells.
- Globular cells receive robust GABAergic synaptic inputs from Purkinje cells (PCs).
- 5-HT and NA depress GABA release at synapses between PC axon collaterals and globular cells.
- Presynaptic 5-HT1B receptors and α2-adrenoceptors mediate the suppression of GABA release.

Cerebellar Purkinje cells (PCs) project their axon collaterals to underneath of the PC layer and make GABAergic synaptic contacts with globular cells, a subgroup of Lugaro cells. GABAergic transmission derived from the PC axon collaterals is so powerful that it could inhibit globular cells and regulate their firing patterns. However, the physiological properties and implications of the GABAergic synapses on globular cells remain unknown. Using whole-cell patch-clamp recordings from globular cells in the mouse cerebellum, we examined the monoaminergic modulation of GABAergic inputs to these cells. Application of either serotonin (5-HT) or noradrenaline (NA) excited globular cells, thereby leading to their firing. The 5-HT- and NA-induced firing was temporally confined and attenuated by GABAergic transmission, although 5-HT and NA exerted an inhibitory effect on the release of GABA from presynaptic terminals of PC axon collaterals. Agonists for 5-HT1B receptors and α2-adrenoceptors mimicked the 5-HT- and NA-induced suppression of GABAergic activity. Through their differential modulatory actions on the cerebellar inhibitory neural circuits, 5-HT facilitated PC firing, whereas NA suppressed it. These results indicate that 5-HT and NA regulate the membrane excitability of globular cells and PCs through their differential modulation of not only the membrane potential but also GABAergic synaptic circuits. Monoaminergic modulation of the neural connections between globular cells and PCs could play a role in cerebellar motor coordination.

148

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 118, 15 May 2017, Pages 79-89
نویسندگان
, , , ,