کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5549520 | 1556732 | 2017 | 6 صفحه PDF | دانلود رایگان |
The sustained-release properties of the biodegradable nano-drug delivery systems were used to improve the residence time of the chemotherapeutic agent in the body. These drug delivery systems were widely used to deliver chemotherapeutic drugs. The 5-fluorouracil loaded chitosan nanoparticles prepared in this paper have the above advantage. Here, we found that when the mass ratio of 5-fluorouracil and chitosan was 1:1, the maximum drug loading of nanoparticles was 20.13â±â0.007%, the encapsulation efficiency was 44.28â±â1.69%, the particle size was 283.9â±â5.25ânm and the zeta potential was 45.3â±â3.23âmV. The prepared nanoparticles had both burst-release and sustained-release phases in vitro release studies. In addition, the inhibitory effect of the prepared nanoparticles on gastric cancer SGC-7901 cells was similar to that of 5-fluorouracil injection, and the blank vector had no obvious inhibitory effect on SGC-7901 cells. In the pharmacokinetic study of rats in vivo, we found that AUC (0ât), MRT (0ât) and t1/2z of nanoparticles were significantly increased in vivo compared with 5-fluorouracil solution, indicating that the prepared nanoparticles can play a role in sustained-release.
Graphical AbstractThe nanoparticles were prepared by chitosan as carrier and were characterized. In addition, in vitro release studies and in vivo pharmacokinetic studies of nanoparticles were performed.45
Journal: Asian Journal of Pharmaceutical Sciences - Volume 12, Issue 5, September 2017, Pages 418-423