کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5550430 1557291 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide
چکیده انگلیسی

Understanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however up to now its stability behavior was not clear, as few thermodynamic data were available. Therefore, calorimetric melting data have been obtained, which were found to be TI-L = 422.4 ± 1.0 K, ΔI → LH = 117.5 ± 5.2 J g−1, TII-L = 419.8 ± 1.0 K and ΔII → LH = 108.6 ± 3.3 J g−1. In addition, vapor-pressure data, high-pressure melting data, and specific volumes have been obtained. It is demonstrated that form II is intrinsically monotropic in relation to form I and the latter would thus be the best polymorph to use for drug formulations. This result has been obtained by experimental means, involving high-pressure measurements. Furthermore, it has been shown that with very limited experimental and statistical data, the same conclusion can be obtained, demonstrating that in first instance topological pressure-temperature phase diagrams can be obtained without necessarily measuring any high-pressure data. It provides a quick method to verify the phase behavior of the known phases of an active pharmaceutical ingredient under different pressure and temperature conditions.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 525, Issue 1, 15 June 2017, Pages 54-59
نویسندگان
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