کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5552609 1557949 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma
چکیده انگلیسی


- Baicalein possesses potent anti-HCC activity both in vitro and in vivo.
- Baicalein exerts its anti-HCC effect via several cancer-related signaling or molecules.
- Baicalein may be developed as a potential, novel anti-cancer drug for HCC treatment.

Baicalein (5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one) is a flavonoid compound derived from the roots of Scutellaria baicalensis. It has historically been used in anti-oxidant, anti-virus, anti-bacteria, anti-inflammatory and anti-allergic therapies. Recently, baicalein has been found to possess anti-cancer activities via its effect on a variety of biological processes involving cell proliferation, metastasis, apoptosis and autophagy and so on. Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies and high fatality rate worldwide. Noteworthy, treatment protocols of HCC include conventional resection and chemotherapy, all of which may result in enormous mortality rate. Therefore, there is extreme interest to find a relatively non-toxic medicine which may reduce side effects without compromising therapeutic efficacy. Many studies have showed that baicalein is one such potential candidate. In this review, we summarized the various anti-cancer effects of baicalein on HCC and their underlying molecular mechanisms based on in vitro and in vivo experimental evidences discovered so far. Taken together, baicalein may be developed as a potential, novel anticancer drug for HCC treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 93, September 2017, Pages 1285-1291
نویسندگان
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