کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5554644 1558880 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction among hERG channel blockers is a potential mechanism of death in caffeine overdose
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Interaction among hERG channel blockers is a potential mechanism of death in caffeine overdose
چکیده انگلیسی

Caffeine overdose death is due to cardiac arrest, but its mechanism has not been explored in detail. In this study, our data showed that caffeine significantly prolonged the heart rate-corrected QT interval (QTc) of rabbits in vivo (P<0.05; n=7). Caffeine was also found to be a hERG channel blocker with an IC50 of 5.04 mM (n=5). Although these two findings likely link caffeine overdose death with hERG channel blockade, the amount of caffeine consumption needed to reach the IC50 is very high. Further study demonstrated that addition another hERG blocker could lower the consumption of caffeine significantly, no matter whether two hERG blockers share the same binding sites. Our data does not rule out other possibility, however, it suggests that there is a potential causal relationship between caffeine overdose death with hERG channel and the interaction among these hERG blockers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 800, 5 April 2017, Pages 23-33
نویسندگان
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