کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5554990 1559623 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity
چکیده انگلیسی

The present study aimed at the phytochemical and pharmacological investigation of Sideritis montana L. (Lamiaceae). Two new abietane diterpenes [sideritins A (1) and B (2)] were isolated from the methanol extract of the plant. Six known compounds [pomiferin E (3), 9α,13α-epi-dioxyabiet-8(14)-en-18-ol (4), paulownin (5), 6-methoxysakuranetin (6), 3-oxo-α-ionol (7) and 4-allyl-2,6-dimethoxyphenol glucoside (8)] were also obtained from the plant. The structures were determined by means of HREIMS and NMR experiments. The antiproliferative effect of the isolated compounds was investigated on human cancer cell lines (HeLa, SiHa and C33A) at 10 and 30 μM concentrations, using the MTT assay. The results demonstrated that pomiferin E (3) and 6-methoxysakuranetin (6) displayed considerable activity [inhibition (%) ± SEM: 46.93 ± 2.35 on HeLa (pomiferin E), and 51.52 ± 2.45 on C33A (6-methoxysakuranetin)] at 30 μM concentration.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 122, October 2017, Pages 90-94
نویسندگان
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