کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5556338 1560364 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antioxidative and anticancer properties of Licochalcone A from licorice
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Antioxidative and anticancer properties of Licochalcone A from licorice
چکیده انگلیسی

Ethnopharmacological relevanceLicochalcone A (LCA) is a characteristic chalcone that is found in licorice, which is a traditional medicinal plant. In traditional medicine, LCA possesses many potential biological activities, including anti-parasitic, anti-inflammatory and antitumor activities.Aim of the studyTo determine the antioxidant activity of LCA and, on this basis, to investigate the role of its anticancer activity.Materials and methodsTo validate the antioxidant activity of LCA, the proteins SOD, CAT and GPx1 were analyzed using western blotting and cellular antioxidant activity (CAA) assays. Oxidative free radicals are associated with cancer cells. Therefore, the anticancer activity of LCA was also evaluated. To assess the anticancer activity, cell viability assays were performed and apoptosis was evaluated. In addition, MAPK-related proteins were analyzed using western blotting.ResultsThe experimental data showed that the EC50 of LCA is 58.79±0.05 μg/mL and 46.29±0.05 μg/mL under the two conditions tested, with or without PBS. In addition, LCA at a concentration of approximately 2-8 μg/mL can induce the expression of SOD, CAT and GPx1 proteins. Further, LCA inhibits the growth of HepG2 cells through cell proliferation arrest and the subsequent induction of apoptosis, and LCA attenuated the p38/JNK/ERK signaling pathway in a dose-dependent manner.ConclusionThe results showed that LCA suppresses the oxidation of cells and markedly inhibits the proliferation of cancer cells. These findings confirm the traditional use of LCA in folk medicine.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 198, 23 February 2017, Pages 331-337
نویسندگان
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