کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5560067 | 1403308 | 2017 | 7 صفحه PDF | دانلود رایگان |
- (p-ClPhSe)2 had an insulin-mimetic action in vitro.
- (p-ClPhSe)2 reduced glycemia increase in fructose-fed rats.
- (p-ClPhSe)2 stimulates carbohydrate metabolism in fructose-fed rats.
- (p-ClPhSe)2 restored the hepatic metabolic homeostasis in fructose-fed rats.
The modern life leads to excess consumption of food rich in fructose; however, the long-term changes in carbohydrate and lipid metabolism could lead to metabolic dysfunction in humans. The present study evaluated the in vitro insulin-mimetic action of p-chloro-diphenyl diselenide (p-ClPhSe)2. The second aim of this study was to investigate if (p-ClPhSe)2 reverses metabolic dysfunction induced by fructose load in Wistar rats. The insulin-mimetic action of (p-ClPhSe)2 at concentrations of 50 and 100 μM was determined in slices of rat skeletal muscle. (p-ClPhSe)2 at a concentration of 50 μM stimulated the glucose uptake by 40% in skeletal muscle. A dose-response curve revealed that (p-ClPhSe)2 at a dose of 25 mg/kg reduced (â¼20%) glycemia in rats treated with fructose (5 g/kg, i.g.). The administration of fructose impaired the liver homeostasis and (p-ClPhSe)2 (25 mg/kg) protected against the increase (â¼25%) in the G-6-Pase and isocitrate dehydrogenase activities and reduced the triglyceride content (â¼25%) in the liver. (p-ClPhSe)2 regulated the liver homeostasis by stimulating hexokinase activity (â¼27%), regulating the TCA cycle activity (increased the ATP and citrate synthase activity (â¼15%)) and increasing the glycogen levels (â¼67%). In conclusion, (p-ClPhSe)2 stimulated carbohydrate metabolism and reversed metabolic dysfunction in rats fed with fructose.
Journal: Food and Chemical Toxicology - Volume 107, Part A, September 2017, Pages 122-128